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Article

Replication Stress Response Modifies Sarcomeric Cardiomyopathy Remodeling.

Journal of the American Heart Association - 3 Aug 2021

Pal Soumojit, Nixon Benjamin R, Glennon Michael S, Shridhar Puneeth, Satterfield Sidney L, Su Yan Ru, Becker Jason R

Abstract excerpt

Background Sarcomere gene mutations lead to cardiomyocyte hypertrophy and pathological myocardial remodeling. However, there is considerable phenotypic heterogeneity at both the cellular and the organ level, suggesting modifiers regulate the effects of these mutations. We hypothesized that sarcomere dysfunction leads to cardiomyocyte genotoxic stress, and this modifies pathological ventricular remodeling. Methods...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34323119
DOI: 10.1161/JAHA.121.021768
PMCID: PMC8475701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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