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Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis

7 Jul 2015

Abstract excerpt

Homozygous cardiac myosin binding protein C-deficient (Mybpc(t/t)) mice develop dramatic cardiac dilation shortly after birth; heart size increases almost twofold. We have investigated the mechanism of cardiac enlargement in these hearts. Throughout embryogenesis myocytes undergo cell division while maintaining the capacity to pump blood by rapidly disassembling and reforming myofibrillar components of the...

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PMID: 26153423
DOI: 10.1073/pnas.1511004112

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