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BMP signaling promotes heart regeneration via alleviation of replication stress

2024-05-26

Abstract excerpt

One hallmark of aging is a decline in tissue regeneration, which can be caused by DNA replication stress. Whether highly regenerative species like zebrafish are immune from such hindrances to replication is unknown. In contrast to most mammals, adult zebrafish achieve complete heart regeneration via cell cycle entry and proliferation of mature cardiomyocytes. We found that cycling cardiomyocytes experience replica...

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Identifiers and source

Literature Corpus work
b6249687-d6e1-565b-9c71-c9028da9eceb
DOI
10.1101/2024.05.24.595503
Open publication

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BMP signaling promotes heart regeneration via alleviation of replication stressDOI 10.1101/2024.05.24.595503
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