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Article

A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations

13 Dec 2018

Abstract excerpt

Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disorder of heart muscle thickening associated with sudden cardiac death and heart failure, with unclear mechanisms. We engineered four isogenic induced pluripotent stem cell (iPSC) models of β-myosin heavy chain and myosin-binding protein C3 mutations, and studied iPSC-derived cardiomyocytes in cardiac microtissue...

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Identifiers

PMID: 30554920
DOI: 10.1016/j.stemcr.2018.11.015

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