Article
Loss-of-function mutations in the filaggrin gene and alopecia areata: strong risk factor for a severe course of disease in patients comorbid for atopic disease.
The Journal of investigative dermatology - 1 Nov 2007
Betz Regina C, Pforr Jana, Flaquer Antonia, Redler Silke, Hanneken Sandra, Eigelshoven Sibylle, Kortüm Anne-Katrin, Tüting Thomas, Lambert Julien, De Weert Jozef, Hillmer Axel M, Schmael Christine, Wienker Thomas F, Kruse Roland, Lutz Gerhard, Blaumeiser Bettina, Nöthen Markus M
Abstract excerpt
Alopecia areata (AA) is a common dermatological disease, which affects nearly 2% of the general population. Association of AA with atopic disease has been repeatedly reported. Loss-of-function mutations in the filaggrin gene (FLG) may be considered as promising candidates in AA, as they have been observed to be a strong risk factor in atopic dermatitis. The FLG mutations R501X and 2282del4 were genotyped in a...
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