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Article

Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate.

Journal of dermatological science - 1 Oct 2014

Sasaki Takashi, Furusyo Norihiro, Shiohama Aiko, Takeuchi Satoshi, Nakahara Takeshi, Uchi Hiroshi, Hirota Tomomitsu, Tamari Mayumi, Shimizu Nobuyoshi, Ebihara Tamotsu, Amagai Masayuki, Furue Masutaka, Hayashi Jun, Kudoh Jun

Abstract excerpt

BACKGROUND: Filaggrin (FLG) is a major protein component of the stratum corneum (SC) layer, and FLG loss-of-function mutations are a predisposing factor for atopic dermatitis (AD). Previous cohort studies of children from northern and western Europe have reported FLG loss-of-function mutation frequencies of 15.1-20.9% and 5.8-13.0% in AD and non-AD groups, respectively. OBJECTIVE: To elucidate the association...

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Source

Identifiers

PMID: 25086748
DOI: 10.1016/j.jdermsci.2014.06.004

Genes

FLG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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