Article
A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation.
Scientific reports - 28 Jul 2021
Nizami Sohaib, Millar Val, Arunasalam Kanisa, Zarganes-Tzitzikas Tryfon, Brough David, Tresadern Gary, Brennan Paul E, Davis John B, Ebner Daniel, Di Daniel Elena
Abstract excerpt
Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 forms a complex with apoptosis-associated speck-like protein containing a CARD domain (ASC) followed by formation of the active inflammasome. Identification of inhibitors of...
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