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Article

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

1 Jan 2015

Abstract excerpt

The inflammasome is a molecular platform formed by activation of an innate immune pattern recognition receptor seed, such as NLRP3. Once activated, NLRP3 recruits the adapter ASC (apoptosis-related speck-like protein containing a caspase recruitment domain), which in turn recruits procaspase-1. Procaspase-1 autocatalyzes its cleavage and activation, resulting in maturation of the precursor forms of interleukin...

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Share to Autoimmune and Inflammatory Disorders Research
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25653548
DOI: 10.2147/jir.s51250

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