Article

Discovery of a Potent and Selective Inhibitor of Human NLRP3 with a Novel Binding Modality and Mechanism of Action

2024-12-22

Abstract excerpt

<h4>ABSTRACT</h4> The NLRP3 inflammasome is an intracellular protein complex that causes inflammation via the release of IL-1β and pyroptosis. NLRP3 activation is associated with many age-related inflammatory diseases, and NLRP3 inhibition is a promising therapeutic strategy. We previously performed a DNA encoded library screen to identify novel NLRP3 binding molecules. Herein we describe the characterization of...

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Literature Corpus work: a2303d3c-3666-5e07-b865-fe6a6fbe8a88
DOI: 10.1101/2024.12.21.629867

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