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N501Y mutation imparts cross-species transmission of SARS-CoV-2 to mice by enhancing receptor binding

27 Jul 2021

Abstract excerpt

According to the World Health Organization (WHO), as of March 8, 2021, the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) had infected more than 116 million patients with coronavirus disease 2019 (COVID-19) ( https://covid19.who.int ). The high infectivity of SARS-CoV-2 is largely attributable to the unique sequence composition of its spike (S) glycoprotein. During the process of...

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PMID: 34315847
DOI: 10.1038/s41392-021-00704-2

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