Article
Nidogen-2 Maintains the Contractile Phenotype of Vascular Smooth Muscle Cells and Prevents Neointima Formation via Bridging Jagged1-Notch3 Signaling.
Circulation - 12 Oct 2021
Mao Chenfeng, Ma Zihan, Jia Yiting, Li Weihao, Xie Nan, Zhao Guizhen, Ma Baihui, Yu Fang, Sun Jinpeng, Zhou Yuan, Cui Qinghua, Fu Yi, Kong Wei
Abstract excerpt
BACKGROUND: How the extracellular matrix (ECM) microenvironment modulates the contractile phenotype of vascular smooth muscle cells (VSMCs) and confers vascular homeostasis remains elusive. METHODS: To explore the key ECM proteins in the maintenance of the contractile phenotype of VSMCs, we applied protein-protein interaction network analysis to explore novel ECM proteins associated with the VSMC phenotype. By...
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