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Article

Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes.

Vascular pharmacology - 1 Aug 2022

Breikaa Randa M, Denman Kimberly, Ueyama Yukie, McCallinhart Patricia E, Khan Aiman Q, Agarwal Gunjan, Trask Aaron J, Garg Vidu, Lilly Brenda

Abstract excerpt

BACKGROUND: Notch signaling is an evolutionarily conserved pathway that functions via direct cell-cell contact. The Notch ligand Jagged1 (Jag1) has been extensively studied in vascular development, particularly for its role in smooth muscle cell maturation. Endothelial cell-expressed Jag1 is essential for blood vessel formation by signaling to nascent vascular smooth muscle cells and promoting their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

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Identifiers

PMID: 35792302
DOI: 10.1016/j.vph.2022.107087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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