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Asymmetric organelle inheritance predicts human blood stem cell fate

27 Jul 2021

Abstract excerpt

Understanding human hematopoietic stem cell fate control is important for its improved therapeutic manipulation. Asymmetric cell division, the asymmetric inheritance of factors during division instructing future daughter cell fates, was recently described in mouse blood stem cells. In human blood stem cells, the possible existence of asymmetric cell division remained unclear because of technical challenges in its...

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PMID: 34314497
DOI: 10.1182/blood.2020009778

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