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Asymmetric Cell Division and Tumor Heterogeneity

4 Jul 2022

Abstract excerpt

Asymmetric cell division (ACD) gives rise to two daughter cells with different fates after mitosis and is a fundamental process for generating cell diversity and for the maintenance of the stem cell population. The cancer stem cell (CSC) theory suggests that CSCs with dysregulated self-renewal and asymmetric cell division serve as a source of intra-tumoral heterogeneity. This heterogeneity complicates the...

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PMID: 35859890
DOI: 10.3389/fcell.2022.938685

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