Article

Heterotypic interaction promotes asymmetric division of human hematopoietic stem and progenitor cells

2023-09-01

Abstract excerpt

Hematopoietic Stem and Progenitor Cells (HSPCs) give rise to all cell types of the hematopoietic system through various processes including asymmetric divisions. However, the contribution of stromal cells of the hematopoietic niches in the control of HSPC asymmetric divisions remains unknown. Using polyacrylamide microwells as minimalist niches, we show that heterotypic interaction with osteoblast promotes asymmet...

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Literature Corpus work: 1a28c8b2-9085-510a-bb91-1f22ad67fcc9
DOI: 10.1101/2023.08.31.555706

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