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Article

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.

Nature genetics - 1 Mar 2014

Zimdahl Bryan, Ito Takahiro, Blevins Allen, Bajaj Jeevisha, Konuma Takaaki, Weeks Joi, Koechlein Claire S, Kwon Hyog Young, Arami Omead, Rizzieri David, Broome H Elizabeth, Chuah Charles, Oehler Vivian G, Sasik Roman, Hardiman Gary, Reya Tannishtha

Abstract excerpt

Cell fate can be controlled through asymmetric division and segregation of protein determinants, but the regulation of this process in the hematopoietic system is poorly understood. Here we show that the dynein-binding protein Lis1 is critically required for hematopoietic stem cell function and leukemogenesis. Conditional deletion of Lis1 (also known as Pafah1b1) in the hematopoietic system led to a severe...

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Identifiers

PMID: 24487275
DOI: 10.1038/ng.2889
PMCID: PMC4267534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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