Distinguishing different psychiatric disorders using DDx-PRS.

doi:10.1038/s41588-026-02684-x

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Article

Distinguishing different psychiatric disorders using DDx-PRS.

Nature genetics - 1 Sept 2026

Peyrot Wouter J, Panagiotaropoulou Georgia, Olde Loohuis Loes M, Adams Mark J, Andreassen Ole A, Awasthi Swapnil, Forstner Andreas J, Ge Tian, McIntosh Andrew M, Mitchell Brittany L, Mullins Niamh, O'Connell Kevin S, Penninx Brenda W J H, Posthuma Danielle, Ripke Stephan, Ruderfer Douglas M, Uffelmann Emil, Vilhjalmsson Bjarni J, Zhu Zhihong, Smoller Jordan W, Price Alkes L

Abstract excerpt

Despite great progress on case-control polygenic prediction, an unmet need remains for a method that genetically distinguishes clinically related disorders (e.g., schizophrenia (SCZ) versus bipolar disorder (BIP) versus major depressive disorder (MDD) versus controls). We introduce differential diagnosis-polygenic risk score (DDx-PRS), which jointly estimates the posterior probabilities of each diagnostic...

Read the complete abstract on PubMed

Topics

Humans
Genome-Wide Association Study
Bipolar Disorder
Major Depressive Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Schizophrenia

Genetic Risk Score

Genetic Predisposition to Disease

Case-Control Studies

DEAD-box RNA Helicases

Diagnosis, Differential

Mental Disorders

Polymorphism, Single Nucleotide

Multifactorial Inheritance

Source

Open in PubMed Open full text

Identifiers

PMID: 42625058
DOI: 10.1038/s41588-026-02684-x
PMCID: PMC13559851

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