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Induction of CIITA by IFN-γ in macrophages involves STAT1 activation by JAK and JNK

13 Jul 2021

Abstract excerpt

The induction of major histocompatibility complex (MHC) class II proteins by interferon gamma (IFN-γ) in macrophages play an important role during immune responses. Here we explore the signaling pathways involved in the induction by IFN-γ of the MHC II transactivator (CIIta) required for MHC II transcriptional activation. Cyclophilin A (CypA) is required for IFN-γ-dependent induction of MHC II in macrophages, but...

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PMID: 34303919
DOI: 10.1016/j.imbio.2021.152114

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