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Article

The Smad3 Protein Is Involved in TGF-β Inhibition of Class II Transactivator and Class II MHC Expression

1 Jul 2001

Abstract excerpt

TGF-beta is a immunoregulatory cytokine that inhibits class II MHC expression in a variety of cell types. Previous studies have shown that the class II MHC transactivator (CIITA), a master regulator that controls class II MHC expression, is targeted by TGF-beta for repression of IFN-gamma-induced class II MHC expression in astrocytes. The mechanism(s) underlying the TGF-beta inhibitory effect is not understood....

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PMID: 11418665
DOI: 10.4049/jimmunol.167.1.311

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The Smad3 Protein Is Involved in TGF-β Inhibition of Class II Transactivator and Class II MHC ExpressionPMID 11418665Read ↗

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