Article
Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA.
Immunity - 1 May 1997
Gobin S J, Peijnenburg A, Keijsers V, van den Elsen P J
Abstract excerpt
The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site alpha of the MHC class I promoter is essential for the IFN gamma-induced tr...
Topics
- Activating Transcription Factor 1
- Binding Sites
- Cell Membrane
- DNA-Binding Proteins
- Gene Expression Regulation
- Genes, MHC Class I
- HeLa Cells
- Histocompatibility Antigens Class I
- Humans
- Interferon-gamma
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Teratoma
- Trans-Activators
- Transcription Factors
- Transcriptional Activation