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Article

Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA.

Immunity - 1 May 1997

Gobin S J, Peijnenburg A, Keijsers V, van den Elsen P J

Abstract excerpt

The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site alpha of the MHC class I promoter is essential for the IFN gamma-induced transactivation of MHC class I gene expression through the ISRE. Moreover, it was discovered that the class II...

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Source

Identifiers

PMID: 9175838
DOI: 10.1016/s1074-7613(00)80348-9

Genes

CIITA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA.PMID 9175838Read ↗

Induction of MHC class I expression by the MHC class II transactivator CIITA.Semantic proximity Read ↗

The AIR-1 encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and .. more.Semantic proximity Read ↗

Interferon-γ Induction of the Human Leukocyte Antigen-E Gene Is Mediated through Binding of a Complex Containing STAT1α to a Distinct Interferon-γ-responsive ElementSemantic proximity Read ↗

Induction of CIITA by IFN-γ in macrophages involves STAT1 activation by JAK and JNKSemantic proximity Read ↗

Molecular characterization of chicken class II transactivator gene.Semantic proximity Read ↗

The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.Semantic proximity Read ↗

The X1 box of HLA-G promoter is a target site for RFX and Sp1 factors.Semantic proximity Read ↗

Class II transactivator is required for maximal expression of HLA-DOB in B cells.Semantic proximity Read ↗

Identification of a nuclear export sequence in the MHC CIITA.Semantic proximity Read ↗

Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction.Semantic proximity Read ↗

Defective MHC class II expression in an MHC class II deficiency patient is caused by a novel deletion of a splice donor site in the MHC class II transactivator gene.Semantic proximity Read ↗

Patterns of constitutive and IFN-gamma inducible expression of HLA class II molecules in human melanoma cell lines.Semantic proximity Read ↗

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