Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.

Science (New York, N.Y.) - 3 Jun 1994

Darnell J E, Kerr I M, Stark G R

Abstract excerpt

Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kinases of the Jak family that then phosphorylate substrate proteins called STATs (signal transducers and activators of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to Genetic Complementation Test

Share to Molecular Sequence Data

Share to Mutation

Share to Transcription Factors

Source

Identifiers

PMID: 8197455
DOI: 10.1126/science.8197455

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.PMID 8197455Read ↗

Responses to Cytokines and Interferons that Depend upon JAKs and STATs.Semantic proximity Read ↗

The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the NucleusSemantic proximity Read ↗

JAK/STAT-Dependent Gene Regulation by CytokinesSemantic proximity Read ↗

JAKS AND STATS: Biological ImplicationsSemantic proximity Read ↗

IFNs and STATs in innate immunity to microorganismsSemantic proximity Read ↗

JAK-STAT Signaling: From Interferons to CytokinesSemantic proximity Read ↗

JAKs, STATs and signal transduction in response to the interferons and other cytokinesSemantic proximity Read ↗

STAT Transcription Factors in T Cell Control of Health and Disease.Semantic proximity Read ↗

Biology and significance of the JAK/STAT signalling pathways.Semantic proximity Read ↗

Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling PathwaysSemantic proximity Read ↗

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responsesSemantic proximity Read ↗

JAKs go nuclear: Emerging role of nuclear JAK1 and JAK2 in gene expression and cell growthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.