Article
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.
Science (New York, N.Y.) - 3 Jun 1994
Darnell J E, Kerr I M, Stark G R
Abstract excerpt
Through the study of transcriptional activation in response to interferon alpha (IFN-alpha) and interferon gamma (IFN-gamma), a previously unrecognized direct signal transduction pathway to the nucleus has been uncovered: IFN-receptor interaction at the cell surface leads to the activation of kin...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- DNA-Binding Proteins
- Genes
- Genetic Complementation Test
- Humans
- Interferon-Stimulated Gene Factor 3
- Interferon-Stimulated Gene Factor 3, gamma Subunit
- Interferon-alpha
- Interferon-gamma
- Molecular Sequence Data
- Mutation
- Protein-Tyrosine Kinases
- Regulatory Sequences, Nucleic Acid
- Signal Transduction
- Transcription Factors