Article
Identification of 22 susceptibility loci associated with testicular germ cell tumors.
Nature communications - 23 Jul 2021
Pluta John, Pyle Louise C, Nead Kevin T, Wilf Rona, Li Mingyao, Mitra Nandita, Weathers Benita, D'Andrea Kurt, Almstrup Kristian, Anson-Cartwright Lynn, Benitez Javier, Brown Christopher D, Chanock Stephen, Chen Chu, Cortessis Victoria K, Ferlin Alberto, Foresta Carlo, Gamulin Marija, Gietema Jourik A, Grasso Chiara, Greene Mark H, Grotmol Tom, Hamilton Robert J, Haugen Trine B, Hauser Russ, Hildebrandt Michelle A T, Johnson Matthew E, Karlsson Robert, Kiemeney Lambertus A, Lessel Davor, Lothe Ragnhild A, Loud Jennifer T, Loveday Chey, Martin-Gimeno Paloma, Meijer Coby, Nsengimana Jérémie, Quinn David I, Rafnar Thorunn, Ramdas Shweta, Richiardi Lorenzo, Skotheim Rolf I, Stefansson Kari, Turnbull Clare, Vaughn David J, Wiklund Fredrik, Wu Xifeng, Yang Daphne, Zheng Tongzhang, Wells Andrew D, Grant Struan F A, Rajpert-De Meyts Ewa, Schwartz Stephen M, Bishop D Timothy, McGlynn Katherine A, Kanetsky Peter A, Nathanson Katherine L
Abstract excerpt
Testicular germ cell tumors (TGCT) are the most common tumor in young white men and have a high heritability. In this study, the international Testicular Cancer Consortium assemble 10,156 and 179,683 men with and without TGCT, respectively, for a genome-wide association study. This meta-analysis identifies 22 TGCT susceptibility loci, bringing the total to 78, which account for 44% of disease heritability. Men...
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