Article
Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.
Nature genetics - 1 Jul 2017
Wang Zhaoming, McGlynn Katherine A, Rajpert-De Meyts Ewa, Bishop D Timothy, Chung Charles C, Dalgaard Marlene D, Greene Mark H, Gupta Ramneek, Grotmol Tom, Haugen Trine B, Karlsson Robert, Litchfield Kevin, Mitra Nandita, Nielsen Kasper, Pyle Louise C, Schwartz Stephen M, Thorsson Vésteinn, Vardhanabhuti Saran, Wiklund Fredrik, Turnbull Clare, Chanock Stephen J, Kanetsky Peter A, Nathanson Katherine L
Abstract excerpt
The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3,...
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