Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour.

doi:10.1111/j.1365-2605.2011.01162.x

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Article

Genome-wide association studies provide new insights into the genetic basis of testicular germ-cell tumour.

International journal of andrology - 1 Aug 2011

Turnbull C, Rahman N

Abstract excerpt

Testicular germ-cell tumour (TGCT) is the most common cancer in young men, and genetic epidemiological studies suggest that the disease has a strong genetic basis. Until 2009, very little of this genetic component had been explained. Genome-wide association studies have since identified eight SNPs at six loci which together account for approximately 15% of the genetic risk of TGCT and offer novel biological...

Topics

Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Neoplasms, Germ Cell and Embryonal
Polymorphism, Single Nucleotide
Risk Factors
Testicular Neoplasms

Source

Open in PubMed

Identifiers

PMID: 21623831
DOI: 10.1111/j.1365-2605.2011.01162.x

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