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Article

The genomic landscape of testicular germ cell tumours: from susceptibility to treatment.

Nature reviews. Urology - 1 Jul 2016

Litchfield Kevin, Levy Max, Huddart Robert A, Shipley Janet, Turnbull Clare

Abstract excerpt

The genomic landscape of testicular germ cell tumour (TGCT) can be summarized using four overarching hypotheses. Firstly, TGCT risk is dominated by inherited genetic factors, which determine nearly half of all disease risk and are highly polygenic in nature. Secondly KIT-KITLG signalling is currently the major pathway that is implicated in TGCT formation, both as a predisposition risk factor and a somatic driver...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Neoplasms, Germ Cell and Embryonal

Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 27296647
DOI: 10.1038/nrurol.2016.107

Genes

KIT
KITLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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