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Article

Identification of four new susceptibility loci for testicular germ cell tumour.

Nature communications - 27 Oct 2015

Litchfield Kevin, Holroyd Amy, Lloyd Amy, Broderick Peter, Nsengimana Jérémie, Eeles Rosalind, Easton Douglas F, Dudakia Darshna, Bishop D Timothy, Reid Alison, Huddart Robert A, Grotmol Tom, Wiklund Fredrik, Shipley Janet, Houlston Richard S, Turnbull Clare

Abstract excerpt

Genome-wide association studies (GWAS) have identified multiple risk loci for testicular germ cell tumour (TGCT), revealing a polygenic model of disease susceptibility strongly influenced by common variation. To identify additional single-nucleotide polymorphisms (SNPs) associated with TGCT, we conducted a multistage GWAS with a combined data set of >25,000 individuals (6,059 cases and 19,094 controls). We...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

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Source

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Identifiers

PMID: 26503584
DOI: 10.1038/ncomms9690
PMCID: PMC4846317

Genes

GSPT1
GAB2
TFDP2
ZFPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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