Article
Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application.
Andrology - 1 Jan 2015
Litchfield K, Shipley J, Turnbull C
Abstract excerpt
Testicular germ cell tumour (TGCT) is the most common cause of cancer in young men (aged 15-45 years) in many populations. Multiple genome-wide association studies (GWAS) of TGCT have now been conducted, yielding over 25 disease-associated single-nucleotide polymorphism (SNP)s at 19 independent loci. The genes at these loci have provided rich biological and genetic insight into possible mechanisms underlying...
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