Article
Common variants identified in genome-wide association studies of testicular germ cell tumour: an update, biological insights and clinical application.
Andrology - 1 Jan 2015
Litchfield K, Shipley J, Turnbull C
Abstract excerpt
Testicular germ cell tumour (TGCT) is the most common cause of cancer in young men (aged 15-45 years) in many populations. Multiple genome-wide association studies (GWAS) of TGCT have now been conducted, yielding over 25 disease-associated single-nucleotide polymorphism (SNP)s at 19 independent loci. The genes at these loci have provided rich biological and genetic insight into possible mechanisms underlying...
Topics
- Adolescent
- Adult
- Biomarkers, Tumor
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Testing
- Genome-Wide Association Study
- Humans
- Male
- Middle Aged
- Neoplasms, Germ Cell and Embryonal
- Odds Ratio
- Phenotype
- Polymorphism, Single Nucleotide
- Prognosis
- Risk Assessment
- Risk Factors
- Testicular Neoplasms