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Decoding testicular germ cell tumors: integrating risk, biology, and biomarkers into future care.

Gene - 20 Apr 2026

Bowling Gartrell C, Lacson John Charles A, Almeida Andrea A, Rhee Jongeun, Chesnut Gregory T, Nichols Craig R, Kern Sean Q

Abstract excerpt

Testicular germ cell tumors (TGCTs) are the most common cancer among young men of European ancestry. TGCT incidence is rising worldwide while risk factors remain elusive. Genomically, TGCTs have high aneuploidy, low somatic mutational burden, and are globally hypomethylated. TGCT genetics is polygenic, with 78 susceptibility loci identified from large genome-wide association studies. It is highly curable when...

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PMID: 41687980
DOI: 10.1016/j.gene.2026.150044

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