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Article

Testicular germ cell tumours: predisposition genes and the male germ cell niche.

Nature reviews. Cancer - 1 Apr 2011

Gilbert Duncan, Rapley Elizabeth, Shipley Janet

Abstract excerpt

Testicular germ cell tumours (TGCTs) of adults and adolescents are putatively derived from primordial germ cells or gonocytes. Recently reported genome-wide association studies implicate six gene loci that predispose to TGCT development. Remarkably, the functions of proteins encoded by genes within these regions bridge our understanding between the pathways involved in primordial germ cell physiology, male germ...

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Identifiers

PMID: 21412254
DOI: 10.1038/nrc3021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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