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Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages

21 Jul 2021

Abstract excerpt

Elevated infiltration of immunosuppressive alternatively polarized (M2) macrophages is associated with poor prognosis in patients with cancer. The tumor microenvironment remarkably orchestrates molecular mechanisms that program these macrophages. Here we identify a novel role for oncogenic Hedgehog (Hh) signaling in programming signature metabolic circuitries that regulate alternative polarization of...

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PMID: 34289986
DOI: 10.1158/0008-5472.can-20-1723

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