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Intratumoral microbiota-driven macrophage reprogramming in pancreatic cancer via Blautia metabolite 6-hydroxyhexanoic acid

26 Aug 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) exhibits a particularly immunosuppressive microenvironment, which contributes to its poor prognosis and resistance to conventional therapies. Recent studies have highlighted the microbiome as a dynamic regulator of anti-tumor immunity, ultimately contributing to tumor suppression. The tumor microenvironment is increasingly recognized as a dynamic ecosystem where the...

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PMID: 40865404
DOI: 10.1016/j.intimp.2025.115421

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