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Article

The Associations between COMT and MAO-B Genetic Variants with Negative Symptoms in Patients with Schizophrenia.

Current issues in molecular biology - 8 Jul 2021

Madzarac Zoran, Tudor Lucija, Sagud Marina, Nedic Erjavec Gordana, Mihaljevic Peles Alma, Pivac Nela

Abstract excerpt

Negative symptoms of schizophrenia, including anhedonia, represent a heavy burden on patients and their relatives. These symptoms are associated with cortical hypodopamynergia and impaired striatal dopamine release in response to reward stimuli. Catechol-O-methyltransferase (COMT) and monoamine oxidase type B (MAO-B) degrade dopamine and affect its neurotransmission. The study determined the association between...

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Identifiers

PMID: 34287249
DOI: 10.3390/cimb43020045
PMCID: PMC8928957

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