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Article

Genotypic and Haplotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Gene Polymorphisms with Particular Clinical Symptoms in Schizophrenia.

Genes - 27 Jun 2023

Sagud Marina, Tudor Lucija, Nedic Erjavec Gordana, Nikolac Perkovic Matea, Uzun Suzana, Mimica Ninoslav, Madzarac Zoran, Zivkovic Maja, Kozumplik Oliver, Konjevod Marcela, Svob Strac Dubravka, Pivac Nela

Abstract excerpt

Catechol-O-methyl transferase (COMT) gene variants are involved in different neuropsychiatric disorders and cognitive impairments, associated with altered dopamine function. This study investigated the genotypic and haplotypic association of COMT rs4680 and rs4618 polymorphisms with the severity of cognitive and other clinical symptoms in 544 male and 385 female subjects with schizophrenia. COMT rs4818 G carriers...

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Identifiers

PMID: 37510262
DOI: 10.3390/genes14071358
PMCID: PMC10379812

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