Article
Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR.
Molecular and cellular endocrinology - 25 Jan 1999
Gorla-Bajszczak A, Juge-Aubry C, Pernin A, Burger A G, Meier C A
Abstract excerpt
The peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. These ligand-activated transcription factors are implicated in the regulation of lipid metabolism and adipocyte differentiation and in the regulation of anti-inflammatory processes. In order to bind to DNA and activate transcription PPAR requires the formation of heterodimers with the retinoid X...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.