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Article

Androgens enhance the ability of intratumoral macrophages to promote breast cancer progression.

Oncology reports - 1 Sept 2021

Yamaguchi Mio, Takagi Kiyoshi, Sato Masayasu, Sato Ai, Miki Yasuhiro, Onodera Yoshiaki, Miyashita Minoru, Sasano Hironobu, Suzuki Takashi

Abstract excerpt

Androgens are produced locally in breast carcinoma tissues by androgen‑producing enzymes such as 5α‑reductase type 1 (5αRed1) and affect not only breast cancer cells but the tumor microenvironment as well. Tumor‑associated macrophages (TAMs) are primary components of the tumor microenvironment and contribute to tumor progression. Although previous studies suggest that androgen/androgen receptor (AR) signaling in...

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Identifiers

PMID: 34278480
DOI: 10.3892/or.2021.8139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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