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Article

Role of Cyclin D1b in Inducing Macrophages Toward a Tumor-associated Macrophage-like Phenotype in Murine Breast Cancer.

Current medical science - 1 Aug 2023

Xiang Lei, Rao Qi, He Bin, Guo Xiao-Hong, Xu Yun-Dan, Luo Bao-Ping, Zhao Gang, Wu Feng-Hua

Abstract excerpt

OBJECTIVE: Tumor-associated macrophages (TAMs) of the M2 phenotype are frequently associated with cancer progression. Invasive cancer cells undergoing epithelial-mesenchymal transition (EMT) have a selective advantage as TAM activators. Cyclin D1b is a highly oncogenic splice variant of cyclin D1. We previously reported that cyclin D1b enhances the invasiveness of breast cancer cells by inducing EMT. However, the...

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PMID: 37391677
DOI: 10.1007/s11596-023-2762-1

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