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Vitamin D3 reduces the expression of M1 and M2 macrophage markers in breast cancer patients

27 Sept 2024

Abstract excerpt

(VD) is known for its immunomodulatory and anticancer effects. This study aimed to characterize tumor-associated macrophages (TAMs) in breast cancer (BC) and assess the influence of VD and its active metabolite, calcitriol, on their polarization. TAMs were isolated from BC patients and characterized. Monocytes were differentiated into macrophage classes (M0, M1, M2a, M2c) and treated ex vivo with calcitriol. The...

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PMID: 39333342
DOI: 10.1038/s41598-024-73152-x

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