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Article

DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65.

Cell death & disease - 17 Jul 2021

Lin Zixuan, Chen Chen, Yang Dongqin, Ding Jianqing, Wang Guanghui, Ren Haigang

Abstract excerpt

Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterized by progressive neurodegeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). DJ-1 acts essential roles in neuronal protection and anti-neuroinflammatory response, and its loss of function is tightly associated with a familial recessive form of PD. However, the molecular mechanism of DJ-1...

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Identifiers

PMID: 34274951
DOI: 10.1038/s41419-021-04002-1
PMCID: PMC8286256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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