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Article

Crystal Structures of Drug-Metabolizing CYPs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021

Estrada D Fernando, Kumar Amit, Campomizzi Christopher S, Jay Natalie

Abstract excerpt

The complex enzyme kinetics displayed by drug-metabolizing cytochrome P450 enzymes (CYPs) (see Chapter 9 ) can, in part, be explained by an examination of their crystallographic protein structures. Fortunately, despite low sequence similarity between different families of drug-metabolizing CYPs, there exists a high degree of structural homology within the superfamily. This similarity in the protein fold allows...

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Share to Crystallography, X-Ray
Share to Cytochrome P-450 Enzyme System
Share to Inactivation, Metabolic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34272695
DOI: 10.1007/978-1-0716-1554-6_7
PMCID: PMC10813703

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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