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Article

Crystal structure of human cytochrome P450 2D6.

The Journal of biological chemistry - 17 Mar 2006

Rowland Paul, Blaney Frank E, Smyth Martin G, Jones Jo J, Leydon Vaughan R, Oxbrow Amanda K, Lewis Ceri J, Tennant Mike G, Modi Sandeep, Eggleston Drake S, Chenery Richard J, Bridges Angela M

Abstract excerpt

Cytochrome P450 2D6 is a heme-containing enzyme that is responsible for the metabolism of at least 20% of known drugs. Substrates of 2D6 typically contain a basic nitrogen and a planar aromatic ring. The crystal structure of human 2D6 has been solved and refined to 3.0A resolution. The structure shows the characteristic P450 fold as seen in other members of the family, with the lengths and orientations of the...

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Identifiers

PMID: 16352597
DOI: 10.1074/jbc.M511232200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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