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Article

Identifying cytochrome p450 functional networks and their allosteric regulatory elements.

PloS one - 1 Jan 2013

Liu Jin, Tawa Gregory J, Wallqvist Anders

Abstract excerpt

Cytochrome P450 (CYP) enzymes play key roles in drug metabolism and adverse drug-drug interactions. Despite tremendous efforts in the past decades, essential questions regarding the function and activity of CYPs remain unanswered. Here, we used a combination of sequence-based co-evolutionary analysis and structure-based anisotropic thermal diffusion (ATD) molecular dynamics simulations to detect allosteric...

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Identifiers

PMID: 24312617
DOI: 10.1371/journal.pone.0081980
PMCID: PMC3849357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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