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Article

Peptide-MHC class II complex stability governs CD4 T cell clonal selection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2010

Baumgartner Christina K, Ferrante Andrea, Nagaoka Mika, Gorski Jack, Malherbe Laurent P

Abstract excerpt

The clonal composition of the T cell response can affect its ability to mediate infection control or to induce autoimmunity, but the mechanisms regulating the responding TCR repertoire remain poorly defined. In this study, we immunized mice with wild-type or mutated peptides displaying varying binding half-lives with MHC class II molecules to measure the impact of peptide-MHC class II stability on the clonal...

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Share to Autoimmunity
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20007533
DOI: 10.4049/jimmunol.0902107
PMCID: PMC2975033

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