Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationship of 2D Affinity to T Cell Functional Outcomes.

International journal of molecular sciences - 27 Oct 2020

Kolawole Elizabeth M, Lamb Tracey J, Evavold Brian D

Abstract excerpt

T cells are critical for a functioning adaptive immune response and a strong correlation exists between T cell responses and T cell receptor (TCR): peptide-loaded MHC (pMHC) binding. Studies that utilize pMHC tetramer, multimers, and assays of three-dimensional (3D) affinity have provided advancements in our understanding of T cell responses across different diseases. However, these technologies focus on higher...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptive Immunity
Share to Lymphocyte Activation
Share to Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Receptors, Antigen, T-Cell

Share to Surface Plasmon Resonance

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 33120989
DOI: 10.3390/ijms21217969
PMCID: PMC7662510

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationship of 2D Affinity to T Cell Functional Outcomes.PMID 33120989Read ↗

Biology-based AI Predicts T-cell Receptor Antigen Binding SpecificitySemantic proximity Read ↗

Immortalization and functional screening of natively paired human T cell receptor repertoiresSemantic proximity Read ↗

Immortalization and Functional Screening of Natively Paired Human T Cell Receptor RepertoiresSemantic proximity Read ↗

ATLAS: A database linking binding affinities with structures for wild-type and mutant TCR-pMHC complexes.Semantic proximity Read ↗

High-affinity T cell receptor differentiates cognate peptide-MHC and altered peptide ligands with distinct kinetics and thermodynamics.Semantic proximity Read ↗

T cell affinity regulates asymmetric division, effector cell differentiation, and tissue pathology.Semantic proximity Read ↗

High-dimensional analysis of human CD8(+) T cell phenotype, function, and antigen specificity.Semantic proximity Read ↗

TCR affinity and specificity requirements for human regulatory T-cell functionSemantic proximity Read ↗

CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.Semantic proximity Read ↗

A class-mismatched TCR bypasses MHC restriction via an unorthodox but fully functional binding geometrySemantic proximity Read ↗

Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells.Semantic proximity Read ↗

Diversity-oriented approaches for interrogating T-cell receptor repertoire, ligand recognition, and function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.