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Article

Novel role for caspase recruitment domain family member 14 and its genetic variant rs11652075 in skin filaggrin homeostasis.

The Journal of allergy and clinical immunology - 1 Feb 2022

DeVore Stanley B, Stevens Mariana L, He Hua, Biagini Jocelyn M, Kroner John W, Martin Lisa J, Khurana Hershey Gurjit K

Abstract excerpt

BACKGROUND: Low epidermal filaggrin (FLG) is a risk factor for atopic dermatitis (AD) and allergic comorbidity. FLG mutations do not fully explain the variation in epidermal FLG levels, highlighting that other genetic loci may also regulate FLG expression. OBJECTIVE: We sought to identify genetic loci that regulate FLG expression and elucidate their functional and mechanistic consequences. METHODS: A genome-wide...

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Source

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Identifiers

PMID: 34271060
DOI: 10.1016/j.jaci.2021.07.003
PMCID: PMC9119145

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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