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Article

The Genetics and Epigenetics of Atopic Dermatitis-Filaggrin and Other Polymorphisms.

Clinical reviews in allergy & immunology - 1 Dec 2016

Liang Yunsheng, Chang Christopher, Lu Qianjin

Abstract excerpt

Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by a combination of genetic and environmental factors. Genetic evidences depict a complex network comprising by epidermal barrier dysfunctions and dysregulation of innate and adaptive immunity in the pathogenesis of AD. Mutations in the human filaggrin gene (FLG) are the most significant and well-replicated genetic mutation associated with AD,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26385242
DOI: 10.1007/s12016-015-8508-5

Genes

FLG
CLDN1
SPINK5
SPRR3
TSLP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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