Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitis

16 Jan 2024

Abstract excerpt

Background Recent studies have shown that activated pyroptosis in atopic dermatitis (AD) switches inflammatory processes and causes abnormal cornification and epidermal barrier dysfunction. Little research has focused on the interaction mechanism between pyroptosis-related genes and human keratinocyte differentiation. Methods The AD dataset from the Gene Expression Omnibus (GEO) was used to identify differently...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatology and Skin Diseases
Share to Inflammasome and immune disorders
Share to Psoriasis: Treatment and Pathogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38250727
DOI: 10.7717/peerj.16768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GSDMD suppresses keratinocyte differentiation by inhibiting FLG expression and attenuating KCTD6-mediated HDAC1 degradation in atopic dermatitisPMID 38250727Read ↗

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammationSemantic proximity Read ↗

Bioinformatic analysis of key pathways and genes involved in pediatric atopic dermatitis.Semantic proximity Read ↗

Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesisSemantic proximity Read ↗

IL-24 and S100A2 as Novel Immune Drivers for Therapeutic Targeting and Precision Subtyping in Atopic DermatitisSemantic proximity Read ↗

Novel role for caspase recruitment domain family member 14 and its genetic variant rs11652075 in skin filaggrin homeostasis.Semantic proximity Read ↗

Single‐cell RNA ‐seq reveals abnormal differentiation of keratinocytes and increased inflammatory differentiated keratinocytes in atopic dermatitisSemantic proximity Read ↗

A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasiaSemantic proximity Read ↗

Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D MetabolismSemantic proximity Read ↗

Gasdermin E-mediated keratinocyte pyroptosis participates in the pathogenesis of psoriasis by promoting skin inflammationSemantic proximity Read ↗

Transcriptomic Profiling of Lesional and Perilesional Skin in Atopic Dermatitis Suggests Barrier Dysfunction, Inflammatory Activation, and Alterations to Vitamin D MetabolismSemantic proximity Read ↗

Multiple Transcriptome Data Analysis Reveals Biologically Relevant Atopic Dermatitis Signature Genes and PathwaysSemantic proximity Read ↗

Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.