Article
High-density genotyping study identifies four new susceptibility loci for atopic dermatitis.
Nature genetics - 1 Jul 2013
Ellinghaus David, Baurecht Hansjörg, Esparza-Gordillo Jorge, Rodríguez Elke, Matanovic Anja, Marenholz Ingo, Hübner Norbert, Schaarschmidt Heidi, Novak Natalija, Michel Sven, Maintz Laura, Werfel Thomas, Meyer-Hoffert Ulf, Hotze Melanie, Prokisch Holger, Heim Katharina, Herder Christian, Hirota Tomomitsu, Tamari Mayumi, Kubo Michiaki, Takahashi Atsushi, Nakamura Yusuke, Tsoi Lam C, Stuart Philip, Elder James T, Sun Liangdan, Zuo Xianbo, Yang Sen, Zhang Xuejun, Hoffmann Per, Nöthen Markus M, Fölster-Holst Regina, Winkelmann Juliane, Illig Thomas, Boehm Bernhard O, Duerr Richard H, Büning Carsten, Brand Stephan, Glas Jürgen, McAleer Maeve A, Fahy Caoimhe M, Kabesch Michael, Brown Sara, McLean W H Irwin, Irvine Alan D, Schreiber Stefan, Lee Young-Ae, Franke Andre, Weidinger Stephan
Abstract excerpt
Atopic dermatitis is a common inflammatory skin disease with a strong heritable component. Pathogenetic models consider keratinocyte differentiation defects and immune alterations as scaffolds, and recent data indicate a role for autoreactivity in at least a subgroup of patients. FLG (encoding filaggrin) has been identified as a major locus causing skin barrier deficiency. To better define risk variants and...
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