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Genetics of Atopic Dermatitis: From DNA Sequence to Clinical Relevance

1 Jan 2019

Abstract excerpt

Atopic dermatitis (AD) is a complex disease that is thought to be triggered by environmental factors in genetically susceptible individuals. Twin studies have estimated the heritability of AD to be approximately 75%, with the null (loss-of-function) mutations of the gene encoding filaggrin (FLG) (chromosome 1q21.3) as the strongest known genetic risk factor. The discovery of the filaggrin gene was important in...

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PMID: 31203284
DOI: 10.1159/000500402

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