Article
SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients.
Annals of hematology - 1 Oct 2021
Wang Shuwen, Zhang Xiaoyu, Leng Shaoqiu, Zhang Yanqi, Li Ju, Peng Jun, Zhou Zeping, Feng Qi, Hu Xiang
Abstract excerpt
BACKGROUND: Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by decreased platelet count. While corticosteroids are a useful first-line therapy for ITP patients, their long-term effectiveness is limited, and the determinants of corticosteroid sensitivity in ITP patients remain largely unknown. Sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, is related to the...
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