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Article

Single Nucleotide Polymorphisms of the HIF1A Gene are Associated With Sensitivity of Glucocorticoid Treatment in Pediatric ITP Patients.

Journal of pediatric hematology/oncology - 1 May 2023

Gu Hao, Xie Xingjuan, Ma Jingyao, Fu Lingling, Ma Jie, Wu Runhui, Chen Zhenping

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor-1α (HIF-1α) plays a crucial role in both innate and adaptive immunity. Emerging evidence indicates that HIF-1α is associated with the inflammation and pathologic activities of autoimmune diseases, suggesting that HIF1α may be involved in immune dysregulation in patients with immune thrombocytopenia (ITP). The purpose of this study was to evaluate whether single nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35537010
DOI: 10.1097/MPH.0000000000002483

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